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For every phosphate group added, there are specific lipid kinases — and phosphatases to remove it.

Phospholipid subcellular localization and dynamics

Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation | Physiological Reviews

Subcellular Biochemistry Free Preview. In depth discussion of the state of the art of phosphoinositide research Experts in the field discussing the 'hot' topics in phosphoinositide research A volume dedicated to the enzymes involved in the synthesis and degradation of phosphoinositides see more benefits. Changes in the balance between receptor retrieval from and delivery to the plasma membrane effectively modulate the strength and duration of a cell's response to a given extracellular stimulus. However, some receptors resume signalling after their internalization and, in these cases, the final output of the signalling process might differ notably from that elicited at the plasma membrane.


In the past few years, the role of PIs in cellular signalling and trafficking processes has been firmly established. Although the idea that PIs are localized to distinct subdomains or pools within the same compartment is attractive, at this point it seems difficult to prove experimentally. How enzyme functions are coordinated to avoid a waste of energy remains an open question. We apologize to all those whose studies could not be cited due to space limitations. Nicolaes Tulp Hummel, Celine Alkemade, Gijsje H. Koenderink, Casper C. Email or Customer ID.

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Michele Davies

Forgot your username? Enter your email address below and we will send you your username. Review 1 March full access. Synapse elimination and plasticity in developing human cerebral cortex. American journal of mental deficiency. Extraordinary neoteny of synaptic spines in the human prefrontal cortex. The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, editor. Regional Development of the Brain in Early Life. Philadelphia: F. Davis; Mapping changes in the human cortex throughout the span of life.

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How Enzymes Work

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Coordination between RAB GTPase and phosphoinositide regulation and functions

Immunological reviews. The Biochemical journal. Inositol polyphosphate multikinase signaling in the regulation of metabolism. Annals of the New York Academy of Sciences. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell metabolism.

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